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In wholesome male volunteers, sildenafil at steady state (eighty mg thrice a day) resulted in a 49.8% increase in bosentan AUC and a 42% enhance in bosentan Cmax (125 mg twice a day). Sildenafil had no effect on saquinavir pharmacokinetics (see part 4.2). Stronger CYP3A4 inhibitors akin to ketoconazole and itraconazole can be anticipated to have higher results. Sildenafil (a hundred mg) didn’t have an effect on the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.
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